Chapter 9 Scaling, Actuators and Power in Miniaturized Systems

1. Page 542 The paragraph dealing with luminescence is all wrong. I like to thanks Drs. Jim Zoval (UC Irvine) and Leonidas Bachas (University of Kentucky at Lexington)  for putting me straight on this one

    Certain chemical reactions result in the formation of a fluorescent molecule in its excited state. When this molecule releases its bound energy, a photon (i.e. a light particle) is emitted. This phenomenon is called chemiluminescence or, when appearing in nature, bioluminescence. Fireflies are well-known examples of insects capable of bioluminescence, which is catalyzed by various enzymes called luciferases acting on species-specific luciferins. Fluorescence and photoluminescence are forms of luminescence where the energy is supplied by electromagnetic radiation.   Luminometry, the analytical technique to measure chemi- and bioluminescent reactions, is up to 100,000 times more sensitive than absorption spectroscopy and at least 1,000 times more sensitive than fluorescence. This analytical advantage would position chemiluminescence as the preferred detection method for a miniaturized system.  However, chemiluminescent and bioluminescent detection systems need a reagent addition, as the luminescent signal must be triggered by a chemical or enzymatic reaction. Photoluminescence of an analytical sample is given by (9.8)

                                                                                                                                                                                                                                                                                                            (9.8)

 

where k is a constant, Po is the incident radiant power (W/m2, also called intensity), and C is the concentration of the analyte. This equation is only valid for dilute solutions (i.e., micromolar or less). The k value has a pathlength component, which is the same pathlength as in absorption measurements. On the other hand, bioluminescence and chemiluminescence are based on the total moles of a signaling molecule present and does not have a pathlength component.

2. Page 589, paragraph under Equation 9.112. "From Equation 9.112 we observe that ..." This should read: " From Equation 9.110 we observe that .." Thanks to Mr. William Crumly from Delphi (Irvine, CA).

3. Page 611, reference 154. The date of this reference is 1996 not 1966. Thanks to Peter John Burke (UC Irvine, EE).

4. Page 543, formula 9.14 should be: . Thanks to Dr. Svetlana Tatic-Lucic (Lehigh University).

5. Page 546, the bottom right term of formula 9.20 should be : . Thanks to Dr. Svetlana Tatic-Lucic (Lehigh University).